For what it's worth, I have QB64 installed in two Windows 10 PCs, one with McAfee Enterprise antivirus package, the other using the built-in Windows Defender that comes with Windows 10, and I have not had to do any whitelisting, in either one. In one case, QB64 is unpacked in a folder I call "c:\MyPrograms." In the other, "c:\Documents\MyPrograms."
I'm thinking that MilwJohn may have made life difficult, by unpacking the QB64 files in a Windows-specific folder, as was explained in several posts. But, should be easy enough to find that QB64 folder in there, and blow it away. And then create a new folder for it.